Non-Alcoholic Fatty Liver Disease and Metabolic-Associated Steatotic Liver Disease: Pathogenesis, Staging, and Emerging Therapies

This chapter offers a thorough review of the pathophysiology underlying non-alcoholic fatty liver disease and its progressive form, non-alcoholic steatohepatitis, within the emerging framework of metabolic-associated steatotic liver disease. It details contemporary non-invasive diagnostic modalities — including serum biomarker panels, transient elastography, and multiparametric magnetic resonance imaging — alongside the histopathological staging of fibrosis, and provides a critical assessment of the pharmacological pipeline, encompassing metabolic, anti-fibrotic, and anti-inflammatory agents currently under investigation in phase II and III clinical trials.