Autoimmune Liver Diseases: Autoimmune Hepatitis, Primary Biliary Cholangitis, and Primary Sclerosing Cholangitis

This chapter delivers a detailed synthesis of the diagnosis and management of the three principal autoimmune liver diseases: autoimmune hepatitis, primary biliary cholangitis, and primary sclerosing cholangitis. It reviews updated diagnostic criteria and serological markers, examines the evidence base for first- and second-line immunosuppressive and choleprotective therapies, and critically appraises the pipeline of novel agents — including farnesoid X receptor agonists, fibrates, and anti-fibrotic compounds — that may transform outcomes in these conditions, alongside a discussion of the challenges of managing disease refractory to standard treatment.