Genetic and Hereditary Kidney Diseases: Recent Discoveries and Gene Therapy Prospects

Hereditary nephropathies including Alport syndrome, autosomal dominant polycystic kidney disease, Fabry disease, and podocytopathies are reviewed in the context of recent genomic discoveries that have expanded their genetic landscape. This chapter critically assesses the clinical utility of next-generation sequencing in the diagnostic evaluation of kidney disease and explores the therapeutic promise of gene editing and RNA-targeted strategies.