Hematopoietic Stem Cell Transplantation: Current Indications, Innovations, and Outcomes

This chapter offers a thorough review of the evolving role of hematopoietic stem cell transplantation (HSCT) in hematological malignancies and non-malignant disorders, incorporating advances in conditioning regimens, donor selection, and graft-versus-host disease (GVHD) prophylaxis and management. It addresses the expanded use of haploidentical transplantation, reduced-intensity conditioning, and post-transplant cyclophosphamide-based platforms that have broadened access to transplantation. The chapter also reviews the emerging field of adoptive cellular therapies post-transplant, including donor lymphocyte infusions and virus-specific T cells.