This chapter reviews the evolution and current state of clear aligner therapy, critically assessing the clinical evidence on its efficacy, limitations, and patient-related outcomes in comparison to fixed appliance systems across a spectrum of malocclusion types. It examines advances in digital orthodontic planning, including three-dimensional imaging integration, virtual set-up technologies, and computer-aided biomechanical simulation. Emerging modalities for accelerating orthodontic tooth movement — including photobiomodulation, micro-osteoperforations, and vibration devices — are also evaluated in terms of their biological mechanisms and clinical utility.

Medical Science
Orthodontics in the Digital Era: Clear Aligner Therapy, Accelerated Tooth Movement, and Digital Treatment Planning
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