Bronchiectasis and Cystic Fibrosis: From Mechanisms to Modulator Therapies

This chapter examines the pathophysiology, clinical heterogeneity, and evolving management of bronchiectasis and cystic fibrosis, two airway diseases characterized by chronic infection, inflammation, and progressive structural lung damage. It provides a detailed review of CFTR modulator therapies that have transformed the prognosis of cystic fibrosis, while also addressing the emerging evidence base for treatable traits approaches and individualized management strategies in non-CF bronchiectasis.