Genomics, Epigenetics, and Molecular Mechanisms of Cardiovascular Disease

This chapter provides a comprehensive review of the genomic and epigenetic underpinnings of major cardiovascular diseases, including coronary artery disease, cardiomyopathies, and hereditary arrhythmia syndromes. It critically examines findings from genome-wide association studies, whole-exome sequencing, and single-cell transcriptomics, while highlighting the emerging roles of DNA methylation, histone modification, and non-coding RNAs in cardiac pathophysiology. The chapter further explores how molecular insights are being translated into precision medicine strategies and novel therapeutic targets.