Rheumatoid Arthritis: Pathobiology, Treat-to-Target Strategies, and Novel Therapeutics

This chapter presents a detailed review of the molecular mechanisms driving synovial inflammation and joint destruction in rheumatoid arthritis, integrating findings from genomic, epigenomic, and transcriptomic studies. Current evidence guiding treat-to-target strategies is synthesised alongside a critical evaluation of biologic DMARDs, targeted synthetic agents including JAK inhibitors, and the emerging therapeutic potential of cell-based and RNA-targeted approaches.