Schizophrenia and Psychotic Disorders: Current Concepts and Treatment Advances

This chapter reviews the evolving conceptual and therapeutic landscape of schizophrenia and related psychotic disorders, integrating recent findings from cognitive neuroscience, neuroimaging, and clinical pharmacology. It examines updated models of psychosis pathogenesis, including dopamine-glutamate interactions, immune dysregulation, and developmental trajectory hypotheses, alongside new findings on cognitive impairment and negative symptoms. The chapter critically appraises advances in antipsychotic pharmacotherapy, psychosocial rehabilitation, and early intervention strategies.