Sepsis and Septic Shock: Updated Definitions, Diagnostics, and Therapeutics

Incorporating the Sepsis-3 definitions and post-ProCESS, ARISE, and ProMISe trial era evidence, this chapter traces the evolution of sepsis management from early goal-directed therapy to individualised, pathophysiology-informed resuscitation strategies. It reviews advances in biomarker-guided diagnosis, source identification, antimicrobial stewardship, vasopressor selection, adjunctive therapies, and the growing body of evidence on long-term outcomes and post-sepsis syndrome.