Immunopathogenesis of Inflammatory Skin Diseases: New Frontiers

This chapter provides a comprehensive synthesis of current knowledge on the immune mechanisms underlying major inflammatory dermatoses, including atopic dermatitis, psoriasis, and hidradenitis suppurativa, with a focus on cytokine networks and T-cell subset dynamics. It critically reviews how recent discoveries in type 2 and type 17 immunity have driven the development of targeted biologics and small molecules. The chapter also highlights emerging concepts such as skin-resident memory T cells and epithelial barrier dysfunction as central drivers of chronicity and disease recurrence.